KSHV Manipulates Notch Signaling by DLL4 and JAG1 to Alter Cell Cycle Genes in Lymphatic Endothelia
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چکیده
منابع مشابه
KSHV Manipulates Notch Signaling by DLL4 and JAG1 to Alter Cell Cycle Genes in Lymphatic Endothelia
Increased expression of Notch signaling pathway components is observed in Kaposi sarcoma (KS) but the mechanism underlying the manipulation of the canonical Notch pathway by the causative agent of KS, Kaposi sarcoma herpesvirus (KSHV), has not been fully elucidated. Here, we describe the mechanism through which KSHV directly modulates the expression of the Notch ligands JAG1 and DLL4 in lymphat...
متن کامل[Dll4/Notch signaling pathway and tumor angiogenesis.].
Dll4是定位于人染色体15q14、基因编码长度为685 个氨基酸的单链跨膜蛋白。它在进化过程中高度保守, 人和鼠Dll4基因编码的蛋白具有87%的同源序列。Dll4 的胞外段含有与Notch受体结合必需的8个表皮生长因子 (epidermal growth factor, EGF)样重复序列、4个潜在的 糖基化位点和1个由45个氨基酸组成的保守DSL(Delta, Serrate, Lag2)结构域。 Dll4通过与相邻细胞膜上的Notch1或Notch4受体相 互结合,使Notch受体经过一系列蛋白酶裂解。这个过 程主要包含2个蛋白酶,即肿瘤坏死因子α转换酶(tumor necrosis factor α-converzyme, TACE)和早老素(presenilin) 或称为γ-分泌酶(γ-secretase),受体裂解后释放出活化 形式的胞内区域(notch intrace...
متن کاملKSHV-induced notch components render endothelial and mural cell characteristics and cell survival.
Kaposi sarcoma-associated herpesvirus (KSHV) infection is essential to the development of Kaposi sarcoma (KS). Notch signaling is also known to play a pivotal role in KS cell survival and lytic phase entrance of KSHV. In the current study, we sought to determine whether KSHV regulates Notch components. KSHV-infected lymphatic endothelial cells showed induction of receptors Notch3 and Notch4, No...
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Tumor angiogenesis is an important target for cancer therapy, with most current therapies designed to block the VEGF signaling pathway. However, clinical resistance to anti-VEGF therapy highlights the need for targeting additional tumor angiogenesis signaling pathways. The endothelial Notch ligand Dll4 (delta-like 4) has recently emerged as a critical regulator of tumor angiogenesis and thus as...
متن کاملDll4–Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice
Delta-like ligand 4 (Dll4)-Notch signaling is essential for T cell development and alternative thymic lineage decisions. How Dll4-Notch signaling affects pro-T cell fate and thymic dendritic cell (tDC) development is unknown. We found that Dll4 pharmacological blockade induces accumulation of tDCs and CD4(+)CD25(+)FoxP3(+) regulatory T cells (T(reg) cells) in the thymic cortex. Both genetic ina...
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ژورنال
عنوان ژورنال: PLoS Pathogens
سال: 2009
ISSN: 1553-7374
DOI: 10.1371/journal.ppat.1000616